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Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes

Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes

Series: Theoretical Neuroscience Journal Club
Location: Math 102
Presenter: Erik Larsen, Neuroscience GIDP

On Monday, October 24, Erik Larsen from the Neuroscience GIDP will present the following paper on the molecular aspect of synaptic vesicle fusion:

"Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes" by Mohrmann et al., Science (2010)

An editor of Science wrote about this paper: "The molecular machinery mediating membrane fusion during secretion from a cell requires a complex of so-called SNARE protein that forms a coiled bundle of four parallel α-helices. Mohrmann et al. developed an elegant approach to find out how many SNARE complexes are required to promote secretion of individual secretory vesicles in living chromaffin cells by titrating the ratio of wild-type and mutant SNARE proteins expressed. For fast synchronous release, a minimum of three SNARE complexes per vesicle were required. Fewer SNARE complexes resulted in slower release."

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