The University of Arizona

Center for Innovation in Brain Science and TRIPODS Challenge: Detecting the Cure Zone for Neurodegenerative Disease

Center for Innovation in Brain Science and TRIPODS Challenge: Detecting the Cure Zone for Neurodegenerative Disease

Series: Tripods
Location: ENR 2 S215
Presenter: Roberta Diaz Brinton, Ph.D., Director, Center for Innovation in Brain Science, University of Arizona

Neurodegenerative diseases are progressive in nature. The progressive feature of neurodegeneration is in reality a complex set of sequential systems biology adaptations that first emerge during the prodromal phase of the disease and are ultimately expressed as the end stage state of the disease. Because of the progressive nature, pathways involved in the disease process will change with advancing stages of the disease.

The neurodegenerative diseases, Alzheimer’s (AD), Parkinson’s (PD), Multiple Sclerosis (MS) and Amyotrophic Lateral Sclerosis (ALS), share three common features: 1) a prodromal phase characterized by decline in bioenergetic capacity of the brain, 2) sex differences in prevalence and 3) emergence of risk during transition states. AD, PD, MS and ALS can emerge during transition states that are coincident with critical periods of neural restructuring and bioenergetic demand.

A key Cure Zone challenge is to reliably detect the earliest phase of the disease when the potential for reversing the disease process is greatest.

Pizza, tea, and coffee will be served starting at 11:20am

Department of Mathematics, The University of Arizona 617 N. Santa Rita Ave. P.O. Box 210089 Tucson, AZ 85721-0089 USA Voice: (520) 621-6892 Fax: (520) 621-8322 Contact Us © Copyright 2018 Arizona Board of Regents All rights reserved