Quantitative Biology Colloquium
Spring 2012
Schedule
4:00-5:00 Tuesdays
Mathematics
402
|
January 31 |
Arizona Research
Laboratories Genetic
Signatures of Archaic Introgression in Modern Humans |
|
February 7 |
Susan Hester Department of Molecular and
Cellular Biology A
Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation Abstract. Somitogenesis, the formation of the bodyÕs primary segmental
structure common to all vertebrate development, requires coordination between
biological mechanisms at several scales. Explaining how these mechanisms
interact across scales and how events are coordinated in space and time is
necessary for a complete understanding of somitogenesis
and its evolutionary flexibility. So far, mechanisms of somitogenesis
have been studied independently. To test the consistency, integrability
and combined explanatory power of current prevailing hypotheses, we built an
integrated clock-and-wavefront model including submodels of the intracellular segmentation clock,
intercellular segmentation-clock coupling via Delta/Notch signaling, an FGF8 determination
front, delayed differentiation, clock-wavefront
readout, and differential-cell-cell-adhesion-driven cell sorting. We
identified inconsistencies between existing submodels
and gaps in the current understanding of somitogenesis
mechanisms, and proposed novel submodels and
extensions of existing submodels where necessary. For reasonable initial conditions, 2D
simulations of our model robustly generate spatially and temporally regular somites, realistic dynamic morphologies and spontaneous emergence
of anterior-traveling stripes of Lfng. In this
talk, I will introduce the current prevailing models of somitogenesis
as well as our own novel or extended submodels,
discuss how we implemented previous and novel submodels
in our integrated computational model, and highlight our key results. |
|
February 14 |
Department
of Mathematics University
of British Columbia Stochastic Dynamics of HIV
infection, Prophylaxis and Treatment |
|
February 21 |
Departments
of Physiology and Neuroscience Reanimation of Movement
using Probabilistic Control of Muscle Stimulation |
|
February 28 |
Department
of Agricultural & Biosystems Engineering Estimation of Relative
Abundance of Multiple Genomes in a Metagenomic
Sample Based on Next Generation Sequencing Data |
|
March 6 |
Department
of Ecology and Environmental Biology Ecology and Evolution of a
Social Dilemma in the Toxic Alga Prymnesium parvum |
|
March 13 |
Spring Break |
|
March 20 |
Department of Chemistry and
Biochemistry Membrane-Curvature-Mediated
Interactions |
|
March 27 |
Departments of Ecology and
Environmental Biology and Mathematics University of Michigan |
|
April 3 |
Departments of Mathematics
and Biology Utah State University Emerging
at the Right Time, Stopping at the Right Place, and Scaling Up the Right Way:
Phenology and Differential Motility Describe Patterns of Bark Beetle Outbreak |
|
April 10 |
Program in Applied Mathematics Modeling
RNA Translation with Frameshifts |
|
April 17 |
Department of Ecology and
Environmental Biology Reconstructing
Deep Homologies in the Tree of Life |