Modeling Projects

Viral infections

- Modeling HIV infection

The first paper describes how to turn known experimental observations into a kinetic model for the response to HIV infection. The second article models the competition between different viral strains within a single host.

• Two types of cytotoxic lymphocyte regulation explain kinetics of immune response to human immunodeficiency virus, by I. M. Rouzine, R. A. Sergeev, and A. I. Glushtsov,
  Proc. Natl. Acad. Sci. 103, 666-671 (2006).
• Modeling viral coevolution: HIV multi-clonal persistence and competition dynamics, by F. Bagnoli, P. Liò, L. Sguanci,
  Physica A 366 333-346 (2006).

- Modeling Hepatitis C infection

• Link to a series of review articles on Hepatitis C published in Nature.
• Modelling how ribavirin improves interferon response rates in hepatitis C virus infection, by N.M. Dixit, J.E. Layden-Almer, T. J. Layden, and A.S. Perelson,
  Nature 432, 922-924 (2004).

- Modeling Hepatitis B infection

• Dynamics of hepatitis B virus clearance in chimpanzees, by J.M. Murray, S.F. Wieland, R.H. Purcell, and F.V. Chisari,
  Proc. Natl. Acad. Sci. 102, 17790-17785 (2005).

- Antibody-dependent enhancement

• Dynamic effects of antibody-dependent enhancement on the fitness of viruses, by D.A.T. Cummings, I.B. Schwartz, L. Billings, L.B. Shaw, and D.S. Burke,
  Proc. Natl. Acad. Sci. 102, 15259-15264 (2005).