Walter W. Piegorsch

University of Arizona, Tucson, AZ


EDUCATION:


PROFESSIONAL EXPERIENCE:

Primary

Professor: 14 August 2006 to present,
Department of Mathematics, University of Arizona, Tucson, AZ.

Director, Statistical Research & Education: 8 October 2007 to present, BIO5 Institute, University of Arizona, Tucson, AZ.

Current

Member: 27 April 2018 to present, Data Science Institute, University of Arizona, Tucson, AZ.

Affiliated Faculty: 1 January 2017 to present, Southwest Environmental Health Sciences Center (SWEHSC), University of Arizona, Tucson, AZ.

Affiliated Faculty: 18 February 2016 to present, Center for Biomedical Informatics & Biostatistics (CB2), University of Arizona, Tucson, AZ.

Member: 21 May 2010 to present, Graduate Interdisciplinary Program in Applied Mathematics, University of Arizona, Tucson, AZ.

Affiliate Faculty: 20 April 2010 to present, School of Information: Science, Technology, and Arts (SISTA), University of Arizona, Tucson, AZ.

Professor: 31 December 2007 to present, Department of Biosystems Engineering, University of Arizona, Tucson, AZ.

Member: 11 January 2007 to present, Graduate Interdisciplinary Program in Statistics & Data Science, University of Arizona, Tucson, AZ.

Professor: 1 January 2007 to present, College of Public Health, University of Arizona, Tucson, AZ.

Member, Research Faculty: 14 August 2006 to present, BIO5 Institute, University of Arizona, Tucson, AZ.

Previous

Affiliated Faculty: 15 August 2012 to 17 November 2020, Institute of the Environment, University of Arizona, Tucson, AZ.

Chair: 9 April 2007 to 21 March 2012, Graduate Interdisciplinary Program in Statistics, University of Arizona, Tucson, AZ.

Affiliate Member: 4 May 2007 to 21 May 2010, Graduate Interdisciplinary Program in Applied Mathematics, University of Arizona, Tucson, AZ.

Professor: 1 July 1996 to 15 August 2006, Department of Statistics, University of South Carolina, Columbia, SC.

Research Affiliate: 1 July 2004 to 15 August 2006, Hazards Research Laboratory, University of South Carolina, Columbia, SC.

Member: 3 September 2003 to 30 June 2006, USC NanoCenter, Columbia, SC.

Associated Faculty: 17 October 1995 to 15 May 2006, School of the Environment, University of South Carolina, Columbia, SC.

Adjunct Professor: 1 July 1999 to 15 May 2006, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC.

Senior Scientific Member: 13 February 2004 to 15 May 2006, South Carolina Cancer Center, Columbia, SC.

Adjunct Professor: 1 January 1998 to 31 December 2002, Department of Biostatistics, University of North Carolina, Chapel Hill, NC.

Director of Undergraduate Studies: 16 August 1998 to 15 August 2002, Department of Statistics, University of South Carolina, Columbia, SC.

Adjunct Associate Professor: 29 August 1994 to 30 June 1999, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC.

Adjunct Associate Professor: 1 January 1993 to 31 December 1997, Departments of Statistics and Biostatistics, University of North Carolina, Chapel Hill, NC.

Associate Professor: 16 August 1993 to 30 June 1996, Department of Statistics, University of South Carolina, Columbia, SC.

Adjunct Associate Professor: 1 January 1988 to 31 December 1993, Department of Statistics, North Carolina State University, Raleigh, NC.

Mathematical Statistician: 6 August 1984 to 27 July 1993, Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.


ACCREDITATION:

Accredited Professional Statistician (PStat®),
American Statistical Association, 11 October 2010 to 31 July 2022.


SOCIETY MEMBERSHIPS:


HONORS and OFFICES HELD:

Elected to
Regional Committee/RECOM (2009-2011) of Western North American Region (WNAR), International Biometric Society.

Elected Chairman (2004) of American Statistical Association Section on Statistics and the Environment (Chair-Elect, 2003; Past-Chair, 2005).

Elected to Council (2002-2005) of the International Biometric Society.

Recipient, 2000 University of South Carolina Educational Foundation Research Award for Science, Mathematics, and Engineering.

Elected Vice-Chair (1997-1999) of American Statistical Association Council of Sections.

Fellow (1995), American Statistical Association.

Member (by election, 1995) of the International Statistical Institute.

Elected Secretary (1995-1996) and to Regional Committee/RECOM (1999-2001) of Eastern North American Region (ENAR), International Biometric Society.

Distinguished Achievement Medal (1993), American Statistical Association Section on Statistics and the Environment.

Elected (1983) to New York Alpha Chapter, Mu Sigma Rho, The National Honor Society in Statistics.

Elected (1979) to New York Eta Chapter, Phi Beta Kappa.


COURSES TAUGHT:

North Carolina State University

STAT 511,
Experimental Statistics for the Biological Sciences I

University of South Carolina

STAT 201, Elementary Statistics
STAT 205, Elementary Statistics for the Biological and Life Sciences*
SCCC 312A, Proseminar in Statistics
STAT 511/MATH 511, Probability
STAT 512, Mathematical Statistics
STAT 513, Theory of Statistical Inference
STAT 519, Sampling (and STAT J519: Distance Education version)
STAT 700, Applied Statistics I
STAT 701, Applied Statistics II
STAT 708/BIOS 808, Environmetrics*
STAT 712, Mathematical Statistics I
STAT 713, Mathematical Statistics II
STAT 714, Linear Statistical Models
STAT 715, Analysis of Variance
STAT 775/BIOS 815, Generalized Linear Models*
BIOS 794, Topics in Biostatistics

University of Arizona

ISTA 116, Statistical Foundations for the Information Age*
MATH 263, Introduction to Statistics and Biostatistics
MATH 564/STAT 564, Theory of Probability*
MATH 566/STAT 566, Theory of Statistics*
MATH 571A/STAT 571A, Advanced Statistical Regression Analysis* (and STAT 571A-101: Online version)
STAT 574E/MATH 574E/CPH 574E, Environmental Statistics*
STAT 675, Statistical Computing*

* Developed or co-developed.


STUDENTS SUPERVISED:


SPONSORED RESEARCH:

2020 - 2022: Public Health Service Extramural Research Project #
R21-AI152394, Systems-level genetic patterns underlying disseminated coccidioidomycosis in humans, with Yves A. Lussier (P.I.), et al.

2017 - 2020: National Science Foundation Research Grant #CCF-1740858, UA-TRIPODS - Building theoretical foundations for data sciences, with Hao Helen Zhang (P.I.), et al.

2016 - 2019: Public Health Service Extramural Research Project #R03-ES027394-02, Translational mixed-factor benchmark-dose risk assessment.

2013 - 2014: University of Arizona Online Education Project (OEP): Statistics graduate certificate, with Joseph Watkins (P.I.), Yue Selena Niu, Hao Helen Zhang, Lingling An.

2009 - 2012: Public Health Service Extramural Research Project #R21-ES016791-02, Model-independent benchmark dose estimation for quantitative risk assessment, with Rabi Bhattacharya.

2008 - 2013: Public Health Service Training Grant #T32-ES016652, Human disease and the interplay between genes and the environment, with Terrence J. Monks (P.I.), et al.

2007 - 2009: National Science Foundation Research Grant #CMMI-0623991: The Recovery Divide: Sociospatial disparities in disaster recovery from Hurricane Katrina along Mississippi's gulf coast, with Susan L. Cutter (P.I.), Lynn Weber, Jerry Mitchell, and Mark Smith.

2005 - 2009: Environmental Protection Agency STAR Research Project #RD-832419, Model selection and multiplicity adjustment for benchmark analysis in quantitative risk assessment, with R. Webster West and Edsel A. Peña.

2005 - 2007: Department of Homeland Security National Center for the Study of Terrorism and Responses to Terrorism (START), with Gary La Free (Director), Susan L. Cutter (USC Project Director), et al.

2004 - 2007: National Science Foundation Research Grant #CMS-0433158: Place-based decision support for spatial and temporal transference of risk and hazards, with Susan L. Cutter (P.I.), Madelyn Fletcher, Cary J. Mock, John R. Rose, and John M. Shafer.

2004: South Carolina Biomedical Research Infrastructure Network Award: Multiple comparisons for analysis of mutant spectra, with Don Edwards (P.I.).

2003 - 2007: National Science Foundation Research Grant #SES-0304448: From laboratory to society: Developing an informed approach to nanoscale science and technology, with Davis W. Baird (P.I.), David M. Bérubé, Robert G. Best, Otávio Bueno, R.I.G. Hughes, George Khushf, Loren W. Knapp, Steven W. Lynn, Edward C. Munn, Catherine J. Murphy, Richard P. Ray, Chistopher T. Robinson, Lowndes F. Stephens, and Robin F. Wilson.

2002 - 2003: National Science Foundation Research Grant #CTS-0210552: Philosophical and social dimensions of nanoscale research: Developing a rational approach to a newly emerging science and technology, with Davis W. Baird (P.I.), Alfred Nordmann, David M. Bérubé, Robert G. Best, R.I.G. Hughes, George Khushf, Loren W. Knapp, Steven W. Lynn, Edward C. Munn, Richard P. Ray, Chistopher T. Robinson, Lowndes F. Stephens, Robin F. Wilson, and Christine Schweickert.

2001: Univ. of South Carolina Office of Research Award: Environmental statistics, with Don Edwards (P.I.).

2000: South Carolina Commission on Higher Education Research Project: On the analysis and interpretation of biological sequence data, with Austin L. Hughes (P.I.), László A. Székely, and John R. Rose.

1997 - 2008: Public Health Service Extramural Research Project #R01-CA076031-10, Low-dose risk bounds via simultaneous confidence bands, with R. Webster West and Ralph L. Kodell.

1987 - 1993: Public Health Service Intramural Research Project #Z01-ES048001-06: Statistical analysis of data from genotoxicological experiments.


EDITORIAL ACTIVITIES:

Co-Editor,
Wiley StatsRef: Statistics Reference Online, (2014-present; Founding Co-Editor, 2012).

Honorary Editor, Environmetrics (2020-present; Editor-in-Chief, 2010-2019; Editor, 2009; Associate Editor, 1992-2008).

Joint Editor, Journal of the American Statistical Association Theory & Methods Section (2006-2008; Joint Editor-Elect, 2005; Associate Editor, 1996-2004).

Member, International Advisory Board, Sultan Qaboos University Journal for Science (2004-present).

Member, Editorial Board, Environmental and Ecological Statistics (2004-2011).

Guest Editor, Statistical Science Special Section on Statistics and the Environment, November 2003.

Co-Guest Editor, Environmental and Ecological Statistics Special Issue on Modern Benchmark Analysis for Environmental Risk Assessment, March 2009; Environmetrics Special Issue on Statistical Challenges in Environmental Health, March 2003; Environmetrics Special Issue on Environmental Biometry, December 1993.

Member, Journal Management Committee, Journal of Agricultural, Biological, and Environmental Statistics (2000-2004).

Associate Editor, Biometrics (1997-2004).

Member, Editorial Board, Mutation Research (1994-2008).

Associate Editor, Environmental and Ecological Statistics (1994-2004).

Member, Editorial Board, Environmental and Molecular Mutagenesis (1994-2004).

Member, Editorial Review Board, Environmental Health Perspectives (1993-1996).

Associate Editor, Journal of the American Statistical Association Biopharmaceutical Special Section (1987-1989); Theory & Methods Section (1996-2004).

Refereed over 240 manuscripts for various statistics, mathematics, environmental, epidemiology, toxicology, and scientific journals, and over 70 research proposals for government or external funding agencies.


PRESENTATIONS AT PROFESSIONAL MEETINGS, CONFERENCES, SYMPOSIA, EVENTS: NUMBER OF PUBLICATIONS:


SELECTED PUBLICATIONS:

Piegorsch, W.W.,
Levine, R.A., Zhang, H.H., and Lee, T.C.M. (eds.). Computational Statistics in Data Science. Chichester: John Wiley & Sons (2022).

Aberasturi, D.T., Piegorsch, W.W., Bedrick, E.J., and Lussier, Y.A. Accounting for extra-binomial variability with differentially expressed genetic pathway data: a collaborative bioinformatic study. Stat 12, Article No. e518 (2022).

Liu, J., Piegorsch, W.W., Schissler, A.G., McCaster, R.R., and Cutter, S.L. Adjusting statistical benchmark risk analysis to account for non-spatial autocorrelation, with application to natural hazard risk assessment. Journal of Applied Statistics 49, 2349-2369 (2022).

Aberasturi, D., Pouladi, N., Zaim, S.R., Kenost, C., Berghout, J., Piegorsch, W.W. and Lussier, Y.A. ‘Single-subject studies’-derived analyses unveil altered biomechanisms between very small cohorts: implications for rare diseases. Bioinformatics 37, i67-i75. (2021).

Sans-Fuentes, M.A. and Piegorsch, W.W. Benchmark dose risk analysis with mixed-factor quantal data in environmental risk assessment. Environmetrics 32, Article No. e2677 (2021).

Piegorsch, W.W., McCaster, R.R., and Cutter, S.L. From terrorism to flooding: how vulnerable is your city? Significance 18, 20-25 (2021).

Wheeler, M.W., Piegorsch, W.W. and Bailer, A.J.  Quantal Risk Assessment Database: a database for exploring patterns in quantal dose-response data in risk assessment and its application to develop priors for Bayesian dose-response analysis. Risk Analysis 39, 616-629 (2019).

Liu, J., Piegorsch, W.W., Schissler, A.G., and Cutter, S.L. Autologistic models for benchmark risk or vulnerability assessment of urban terrorism outcomes. Journal of the Royal Statistical Society, Series A (Statistics in Society) 181, 803-823 (2018).

Piegorsch, W.W. Are p-values under attack? Contribution to the discussion of ‘A biostatistician’s view on the current “p-value controversy.” ’ Biometrical Journal 59, 889-891 (2017).

Peña, E.A., Wu, W., Piegorsch, W.W., West, R.W., and An, L. Model selection and estimation with quantal-response data in benchmark risk assessment. Risk Analysis 37, 716-732 (2017).

Schissler, A.G., Li, Q., Chen, J.L., Kenost, C., Achour, I., Billheimer, D.D., Li, H., Piegorsch, W.W., and Lussier, Y.A. Analysis of aggregated cell-cell statistical distances within pathways unveils therapeutic resistance mechanisms in circulating tumor cells. Bioinformatics 32, i80-i89 (2016).

Piegorsch, W.W. Statistical Data Analytics: Foundations for Data Mining, Informatics, and Knowledge Discovery. Chichester: John Wiley & Sons (2015). Also available: Piegorsch, W.W. Statistical Data Analytics, Solutions Manual. Chichester: John Wiley & Sons (2015).

Fang, Q., Piegorsch, W.W., Simmons, S.J., Li, X., Chen, C., and Wang, Y. Bayesian model-averaged benchmark dose analysis via reparameterized quantal-response models. Biometrics 71, 1168–1175 (2015).

Schissler, A.G., Gardeux, V., Li, Q., Achour, I., Li, H., Piegorsch, W.W., and Lussier, Y.A. Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival. Bioinformatics 31, i293-i302 (2015).

Lin, L., Piegorsch, W.W., Bhattacharya, R.N. Nonparametric benchmark dose estimation with continuous dose-response data. Scandinavian Journal of Statistics 42, 713-731 (2015).

Fang, Q., Piegorsch, W.W., and Barnes, K.Y. Bayesian benchmark dose analysis. Environmetrics 26, 373-382 (2015).

Simmons, S.J., Chen, C., Li, X., Wang, Y., Piegorsch, W.W., Fang, Q., Hu, B., and Dunn, G.E. Bayesian model averaging for benchmark dose estimation. Environmental and Ecological Statistics 22, 5-16 (2015).

Piegorsch, W.W. Model uncertainty in environmental dose-response risk analysis. Statistics and Public Policy 1, 79-85 (2014).

Deutsch, R.C., Habing, B.T., and Piegorsch, W.W. A PAV-algorithm approach to detect infinite parameter estimates in one-regressor dose-response models with asymptotes. Journal of Statistical Computation and Simulation 84, 2545-2556 (2014).

Piegorsch, W.W., Xiong, H., Bhattacharya, R.N., and Lin, L. Benchmark dose analysis via nonparametric regression modeling. Risk Analysis 34, 135-151 (2014).

Balakrishnan, N., Brandimarte, P., Everitt, B., Molenberghs, G., Piegorsch, W.W., and Ruggeri, F. (eds.) Wiley StatsRef: Statistics Reference Online, Chichester: John Wiley & Sons (2014).

Cutter, S.L., Emrich, C.T., Mitchell, J.T., Piegorsch, W.W., Smith, M.M., and Weber, L. Hurricane Katrina and the Forgotten Coast of Mississippi. Cambridge: Cambridge University Press (2014).

Piegorsch, W.W., An, L., Wickens, A.A., West, R.W., Peña, E.A., and Wu, W. Information-theoretic model-averaged benchmark dose analysis in environmental risk assessment. Environmetrics 24, 143-157 (2013).

Deutsch, R.C. and Piegorsch, W.W. Benchmark dose profiles for joint-action continuous data in quantitative risk assessment. Biometrical Journal 55, 741-54 (2013).

El-Shaarawi, A.H. and Piegorsch, W.W. (eds.) Encyclopedia of Environmetrics, 2nd edn., Vols. 1-6. Chichester: John Wiley & Sons (2012).

Deutsch, R.C. and Piegorsch, W.W. Benchmark dose profiles for joint-action quantal data in quantitative risk assessment. Biometrics 68, 1313–1322 (2012).

Piegorsch, W.W., Xiong, H., Bhattacharya, R.N., and Lin, L. Nonparametric estimation of benchmark doses in environmental risk assessment. Environmetrics 23, 717–728 (2012).

West, R.W., Piegorsch, W.W., Peña, E.A., An, L., Wu, W., Wickens, A.A., Xiong, H., and Chen, W. The impact of model uncertainty on benchmark dose estimation. Environmetrics 23, 706-716 (2012).

Shane, B.S., Zeiger, E., Piegorsch, W.W., Booth, E.D., Goodman, J.I., and Peffer, R.C. Re-evaluation of the big blue® mouse assay of propiconazole suggests lack of mutagenicity. Environmental and Molecular Mutagenesis 53, 1-9 (2012).

Piegorsch, W.W. and Shaked, M.  The impact of Lehmann's work in applied probability. Selected Works of E.L. Lehmann, J. Rojo (ed.), New York: Springer-Verlag, pp. 807-813 (2012).

Piegorsch, W.W. and Padgett, W.J.  Sequential probability ratio test. International Encyclopedia of Statistical Science, M. Lovric (ed.), Heidelberg: Springer-Verlag, Part 19, pp. 1305-1308 (2011).

Piegorsch, W.W. Translational benchmark risk analysis. Journal of Risk Research 13, 653-667 (2010).

Deutch, R.C., Grego, J.M., Habing, B.T., and Piegorsch, W.W. Maximum likelihood estimation with binary-data regression models: small-sample and large-sample features. Advances and Applications in Statistics 14, 101-116 (2010).

Piegorsch, W.W. and Bailer, A.J.  Combining information. Wiley Interdisciplinary Reviews: Computational Statistics 1, 354-360 (2009).

Liu, W., Hayter, A.J., Piegorsch, W.W., and Al-Khine, P.   Comparison of hyperbolic and constant width simultaneous confidence bands in multiple linear regression under MVCS criterion. Journal of Multivariate Analysis 100, 1432-1439 (2009).

Buckley, B.E., Piegorsch, W.W., and West, R.W. Confidence limits on one-stage model parameters in benchmark risk assessment. Environmental and Ecological Statistics, 16, 53-62 (2009).

West, R.W., Nitcheva, D.K., and Piegorsch, W.W. Bootstrap methods for simultaneous benchmark analysis with quantal response data. Environmental and Ecological Statistics, 16, 63-73 (2009).

Piegorsch, W.W. and Schuler, E.  Communicating the risks, and the benefits, of nanotechnology. International Journal of Risk Assessment and Management 10, 57-69 (2008).

Schmidtlein, M.C., Deutch, R.C., Piegorsch, W.W., and Cutter, S.L.  A sensitivity analysis of the Social Vulnerability Index. Risk Analysis 28, 1099-1114 (2008).

Buckley, B.E. and Piegorsch, W.W. Simultaneous confidence bands for Abbott-adjusted quantal response models. Statistical Methodology 5, 209-219 (2008).

Liu, W., Lin, S., and Piegorsch, W.W.  Construction of exact simultaneous confidence bands for a simple linear regression model. International Statistical Review 76, 39-57 (2008).

Piegorsch, W.W., Cutter, S.L., and Hardisty, F.  Benchmark analysis for quantifying urban vulnerability to terrorist incidents. Risk Analysis 27, 1411-1425 (2007).

Borden, K.A., Schmidtlein, M.C., Emrich, C.T., Piegorsch, W.W. and Cutter, S.L.  Vulnerability of U.S. cities to environmental hazards. Journal of Homeland Security and Emergency Management 4 (2), Art. 5 (2007).

Nitcheva, D.K., Piegorsch, W.W., and West, R.W.  On use of the multistage dose-response model for assessing laboratory animal carcinogenicity. Regulatory Toxicology and Pharmacology 48, 135-147 (2007).

Piegorsch, K.M., Watkins, K.W., Piegorsch, W.W., Reininger, B.M., Corwin, S., and Valois, R.F.  Ergonomic decision-making: A conceptual framework for experienced practitioners from backgrounds in industrial engineering and physical therapy. Applied Ergonomics 37, 587-598 (2006).

Piegorsch, W.W., Nitcheva, D.K., and West, R.W.  Excess risk estimation under multistage model misspecification. Journal of Statistical Computation and Simulation, 76, 423-430 (2006).

Wu, Y., Piegorsch, W.W., West, R.W., Tang, D., Petkewich, M.O., and Pan, W.  Multiplicity-adjusted inferences in risk assessment: Benchmark analysis with continuous response data . Environmental and Ecological Statistics, 13, 125-141 (2006).

Piegorsch, W.W. and West, R.W.  Benchmark analysis: Shopping with proper confidence. Risk Analysis, 25, 913-920 (2005).

Piegorsch, W.W., West, R.W., Pan, W., and Kodell, R.L.  Simultaneous confidence bounds for low-dose risk assessment with non-quantal data. Journal of Biopharmaceutical Statistics 15, 17-31 (2005).

Nitcheva, D.K., Piegorsch, W.W., West, R.W., and Kodell, R.L.  Multiplicity-adjusted inferences in risk assessment: Benchmark analysis with quantal response data. Biometrics 61, 277-286 (2005).

Piegorsch, W.W. and Bailer, A.J.  Analyzing Environmental Data. Chichester: John Wiley & Sons (2005).

Piegorsch, W.W., West, R.W., Pan, W., and Kodell, R.L.  Low-dose risk estimation via simultaneous statistical inferences. Journal of the Royal Statistical Society, series C (Applied Statistics) 54, 245-258 (2005).

Piegorsch, W.W.   Mutagenicity study, Encyclopedia of Biostatistics (2nd edn.), P. Armitage and T. Colton, (eds.) Chichester: John Wiley & Sons, 4, 3590-3595 (2005).

Piegorsch, W.W., Simmons, S.J., and Zeiger, E.  Data mining potency estimators from toxicological databases. Bulletin of Informatics and Cybernetics 36, 51-62 (2004).

Piegorsch, W.W.   Sample sizes for improved binomial confidence intervals. Computational Statistics & Data Analysis 46, 309-316 (2004).

Al-Saidy, O.M., Piegorsch, W.W., West, R.W., and Nitcheva, D.K.  Confidence bands for low-dose risk estimation with quantal response data. Biometrics 59, 1058-1064 (2003).

Gielazyn, M.L., Ringwood, A.H., Piegorsch, W.W., and Stancyk, S.E.  Detection of oxidative DNA damage in isolated marine bivalve hemocytes using the comet assay and formamidopyrimidine glycosylase (Fpg). Mutation Research 542, 15-22 (2003).

Pan, W., Piegorsch, W.W., and West, R.W.  Exact one-sided simultaneous confidence bands via Uusipaikka's method. Annals of the Institute of Statistical Mathematics 55, 243-250 (2003).

Simmons, S.J., Piegorsch, W.W., Nitcheva, D.K., and Zeiger, E. Combining environmental information via hierarchical modeling: An example using mutagenic potencies. Environmetrics 14, 159-168 (2003).

Tu, W. and Piegorsch, W.W. Empirical Bayes analysis for a hierarchical Poisson generalized linear model. Journal of Statistical Planning and Inference 111, 235-248 (2003).

Piegorsch, W.W. and Edwards, D.  What shall we teach in environmental statistics? (with discussion). Environmental and Ecological Statistics 9, 125-150 (2002).

El-Shaarawi, A.H. and Piegorsch, W.W. (eds.) Encyclopedia of Environmetrics Vols. 1-4. Chichester: John Wiley & Sons (2002).

Piegorsch, W.W. and Richwine, K.A. Large-sample pairwise comparisons among multinomial proportions with an application to analysis of mutant spectra. Journal of Agricultural, Biological, and Environmental Statistics 6, 305-325 (2001).

Turner, S.D., Tinwell, H., Piegorsch, W.W., Schmezer, P., and Ashby, J. The male rat carcinogens limonene and sodium saccharin are not mutagenic to male BigBlue(TM) rats. Mutagenesis 16, 329-332 (2001).

Garren, S.T., Smith, R.L., and Piegorsch, W.W. Bootstrap goodness-of-fit test for the beta-binomial model. Journal of Applied Statistics 28, 561-571 (2001).

Garren, S.T., Smith, R.L., and Piegorsch, W.W. On a likelihood-based goodness-of-fit test of the beta-binomial model. Biometrics 56, 947-949 (2000).

Piegorsch, W.W., West, R.W., Al-Saidy, O.M., and Bradley, K.D. Asymmetric confidence bands for simple linear regression over bounded intervals. Computational Statistics & Data Analysis 34, 193-217 (2000).

Bailer, A.J. and Piegorsch, W.W. From quantal counts to mechanisms and systems: The past, present and future of biometrics in environmental toxicology (Editors' Invited Paper). Biometrics 56, 327-336 (2000).

Bailer, A.J. and Piegorsch, W.W. Quantitative potency estimation to measure risk with bio-environmental hazards, Handbook of Statistics Vol. 18: Bioenvironmental and Public Health Statistics, P.K. Sen and C.R. Rao (eds.), New York: North-Holland/Elsevier (2000), pp. 441-463.

Tu, W. and Piegorsch, W.W. Parametric Empirical Bayes estimation for a class of extended log-linear regression models. Environmetrics 11, 271-285 (2000).

Piegorsch, W.W., Simmons, S.J., Margolin, B.H., Zeiger, E., Gidrol, X.M., and Gee, P.  Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay. Mutation Research 467, 11-19 (2000).

Slaton, T.L., Piegorsch, W.W., and Durham, S.D.  Estimation and testing with overdispersed proportions using the beta-logistic regression model of Heckman and Willis. Biometrics 56, 125-132 (2000).

Gielazyn, M.L., Stancyk, S.E., and Piegorsch, W.W. Experimental evidence of subsurface feeding by the burrowing ophiuroid Microphiopholis gracillima (Stimpson) (Echinodermata). Marine Ecology Progress Series 184, 129-138 (1999).

Piegorsch, W.W. Statistical aspects for combining information and meta-analysis in environmental toxicology. Journal of Environmental Science and Health, Part C - Environmental Carcinogenesis & Ecotoxicology Reviews 16, 83-99 (1998).

Nychka, D.K., Cox, L.H., and Piegorsch, W.W. (eds.) Case Studies in Environmental Statistics, New York: Springer-Verlag (1998).

Piegorsch, W.W., Smith, E.P., Edwards, D., and Smith, R.L.  Statistical advances in environmental science. Statistical Science 13, 186-208 (1998).

Piegorsch, W.W.   An introduction to binary response regression and associated trend analyses. Journal of Quality Technology 30, 269-281 (1998).

Piegorsch, W.W. and Bailer, A.J.  Experimental design principles for animal studies in pharmaceutical development. Design and Analysis of Animal Studies in Pharmaceutical Development, S.-C. Chow and J.-P. Liu (eds.), New York: M. Dekker, pp. 23-42 (1998).

Piegorsch, W.W. and Bailer, A.J.  Statistics for Environmental Biology and Toxicology, Boca Raton, FL: Chapman & Hall/CRC Press (1997). Also available: Solutions Manual for Statistics for Environmental Biology and Toxicology, Boca Raton, FL: Chapman & Hall/CRC Press (1999).

Beatty, D.A. and Piegorsch, W.W. Optimal statistical design for toxicokinetic studies. Statistical Methods in Medical Research 6, 359-376 (1997).

Kohlmeier, L., DeMarini, D.M., and Piegorsch W.W. Gene-nutrient interactions in nutritional epidemiology, Design Concepts in Nutritional Epidemiology (2nd edn.), B.M. Margetts and Michael Nelson (eds.) Oxford: Oxford University Press, 312-337 (1997).

Piegorsch, W.W., Lockhart, A.C., Carr, G.J., Margolin, B.H., Brooks, T., Douglas, G.R., Liegibel, U.M., Suzuki, T., Thybaud, V., van Delft, J.H.M., and Gorelick, N.J. Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: An interlaboratory study. Mutation Research 388, 249-289 (1997).

Piegorsch, W.W. and Casella, G.  Empirical Bayes estimation for logistic regression and extended parametric regression models. Journal of Agricultural, Biological, and Environmental Statistics 1, 231-249 (1996).

Cariello, N.F. and Piegorsch, W.W. The Ames test: The two-fold rule revisited. Mutation Research 369, 23-31 (1996).

Green, A.S., Chandler, G.T., and Piegorsch, W.W. Stage-specific toxicity of sediment-associated chlorpyrifos to a marine, infaunal copepod. Environmental Toxicology and Chemistry 15, 1182-1231 (1996).

Cox, L.H. and Piegorsch, W.W. Combining environmental information. I: Environmental monitoring, measurement and assessment. Environmetrics 7, 299-308 (1996).

Piegorsch, W.W. and Cox, L.H. Combining environmental information. II: Environmental epidemiology and toxicology. Environmetrics 7, 309-324 (1996).

Piegorsch, W.W. Statistical analysis of heritable mutagenesis data. Toxicology and Risk Assessment, A.M. Fan and L.W. Chang (eds.), New York: M. Dekker, pp. 473-481 (1996).

Piegorsch, W.W., Margolin, B.H., Shelby, M.D., Johnson, A., French, J.E., Tennant, R.W., and Tindall, K.R. Study design and sample sizes for a lacI transgenic mouse mutation assay. Environmental and Molecular Mutagenesis 25, 231-245 (1995).

Piegorsch, W.W. Empirical Bayes calculations of concordance between endpoints in environmental toxicity experiments (with discussion). Environmental and Ecological Statistics 1, 153-164 (1994).

Cariello, N.F., Piegorsch, W.W., Adams, W.T., and Skopek, T.R. Computer program for the analysis of mutational spectra: application to p53 mutations. Carcinogenesis 15, 2281-2285 (1994).

Haseman, J.K. and Piegorsch, W.W. Statistical analysis of developmental toxicity data. Developmental Toxicology (2nd edn.), C. Kimmel and J. Buelke-Sam (eds.) New York: Raven Press, 349-361 (1994).

Margolin, B.H., Kim, B.S., Smith, M.G., Fetterman, B.A., Piegorsch, W.W., and Zeiger, E. Some comments on potency measures in mutagenicity research. Environmental Health Perspectives 102, Suppl. 1, 91-94 (1994).

Piegorsch, W.W. Statistical models for genetic susceptibility in toxicological and epidemiological investigations. Environmental Health Perspectives 102 Suppl. 1, 77-82 (1994).

Piegorsch, W.W., Weinberg, C.R., and Taylor, J.A.  Non-Hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Statistics in Medicine 13, 153-162 (1994).

Piegorsch, W.W., Lockhart, A.-M.C., Margolin, B.H., Tindall, K.R., Gorelick, N.J., Short, J.M., Carr, G.J., Thompson, E.D., and Shelby, M.D.  Sources of variability from a lacI transgenic mouse mutation assay. Environmental and Molecular Mutagenesis 23, 17-31 (1994).

Piegorsch, W.W. and Bailer, A.J.  Statistical approaches for analyzing mutational spectra: Some recommendations for categorical data. Genetics 136, 403-416 (1994).

Piegorsch, W.W. Environmental Biometry: Assessing impacts of environmental stimuli via animal and microbial laboratory studies. Handbook of Statistics Vol. 12: Environmental Statistics, G.P. Patil and C.R. Rao (eds.), New York: North-Holland/Elsevier, 535-559 (1994).

Piegorsch, W.W. Biometrical methods for testing dose effects of environmental stimuli in laboratory studies. Environmetrics 4, 483-505 (1993).

Thomas, D.C., Nguyen, D.C., Piegorsch, W.W., and Kunkel, T.A.  Relative rates of mutagenic translesion synthesis on the leading and lagging strands during replication of UV-irradiated DNA in a human cell extract. Biochemistry 32, 11476-11482 (1993).

Generoso, W.M. and Piegorsch, W.W. Dominant lethal tests in male and female mice. Male Reproductive Toxicology, R.E. Chapin and J.J. Heindel (eds.) Methods in Toxicology, Vol. 3, New York: Academic Press, 124-141 (1993).

Piegorsch, W.W. and Bailer, A.J.  Minimum mean-square error quadrature. Journal of Statistical Computation and Simulation 46, 217-234 (1993).

Dinse, G.E., Boos, D.D., and Piegorsch, W.W.   Confidence statements about the time range over which survival curves differ. Journal of the Royal Statistical Society, Series C (Applied Statistics) 42, 21-30 (1993).

Piegorsch, W.W. and Taylor, J.A.  Statistical methods for assessing environmental effects on human genetic disorders. Environmetrics 3, 369-384 (1992).

Piegorsch, W.W. Non-parametric methods to assess non-monotone dose response: Applications to genetic toxicology. Order Statistics and Nonparametrics: Theory and Applications, P.K. Sen and I.A. Salama (eds.) Amsterdam: Elsevier/North-Holland, 419-430 (1992).

Lockhart, A.C., Piegorsch, W.W., and Bishop, J.B.  Assessing overdispersion and dose response in the male dominant lethal assay. Mutation Research 272, 35-58 (1992).

Piegorsch, W.W. Complementary log regression for generalized linear models. American Statistician 46, 94-99 (1992).

Gutierrez-Espeleta, G.A., Hughes, L.A., Piegorsch, W.W., Shelby, M.D., and Generoso, W.M. Acrylamide: Dermal exposure produces genetic damage in male mouse germ cells. Fundamental and Applied Toxicology 18, 189-192 (1992).

Piegorsch, W.W., Carr, G.J., Portier, C.J., and Hoel, D.G.  Concordance of carcinogenic response between rodent species: Potency dependence and potential underestimation. Risk Analysis 12, 115-121 (1992).

Generoso, W.M., Shourbaji, A.G., Piegorsch, W.W., and Bishop, J.B.  Developmental responses of zygotes exposed to similar mutagens. Mutation Research 250, 439-446 (1991).

Piegorsch, W.W. and Zeiger, E. Measuring intra-assay agreement for the Ames Salmonella assay. Statistical Methods in Toxicology, L. Hothorn (ed.) Lecture Notes in Medical Informatics, Vol. 43, Heidelberg: Springer-Verlag, 35-41 (1991).

Piegorsch, W.W. Multiple comparisons for analyzing dichotomous response data. Biometrics 47, 45-52 (1991).

Bailer, A.J. and Piegorsch, W.W. Estimating integrals using quadrature methods with an application in pharmacokinetics. Biometrics 46, 1201-1211 (1990).

Piegorsch, W.W. Fisher's contributions to genetics and heredity, with special emphasis on the Gregor Mendel controversy. Biometrics 46, 915-924 (1990).

Whittaker, S.G., Moser, S.F., Maloney, D.H., Piegorsch, W.W., Resnick, M.A., and Fogel, S. The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: Effects of methylbenzimidazol-2-YL carbamate, methyl methanesulfonate, ethyl methane sulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate. Mutation Research 242, 231-258 (1990).

Piegorsch, W.W. Maximum likelihood estimation for the negative binomial dispersion parameter. Biometrics 46, 863-867 (1990).

Whittaker, S.G., Zimmermann, F.K., Dicus, B., Piegorsch, W.W., Resnick, M.A., and Fogel, S. Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae- An interlaboratory assessment of 12 chemicals. Mutation Research 241, 225-242 (1990).

Piegorsch, W.W. One-sided significance tests for generalized linear models under dichotomous response. Biometrics 46, 309-316 (1990).

Piegorsch, W.W. Durand's rules for approximate integration. Historia Mathematica 16, 324-333 (1989).

Piegorsch, W.W. and Bailer, A.J.  Optimal design allocations for estimating area under curves for studies employing destructive sampling. Journal of Pharmacokinetics and Biopharmaceutics 17, 493-507 (1989).

Piegorsch, W.W. and Casella, G.  The early use of matrix diagonal increments in statistical problems. SIAM Review 31, 428-434 (1989). Erratum: Inverting a sum of matrices. SIAM Review 32, 470 (1990).

Whittaker, S.G., Zimmermann, F.K., Dicus, B., Piegorsch, W.W., Fogel, S., and Resnick, M.A.  Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae- An interlaboratory study. Mutation Research 224, 31-78 (1989).

Piegorsch, W.W., Zimmermann, F.K., Fogel, S., Whittaker, S.G., and Resnick, M.A.  Quantitative approaches for assessing chromosome loss in Saccharomyces cerevisiae: general methods for analyzing downturns in dose response. Mutation Research 224, 11-29 (1989).

Rao, G.N., Piegorsch, W.W., Crawford, D.D., Edmondson, J. and Haseman, J.K.  Influence of viral infections on body weight, survival and tumor prevalences of B6C3F1 (C7BL/6N x C3H/HeN) mice in carcinogenicity studies. Fundamental and Applied Toxicology 13, 156-164 (1989).

Piegorsch, W.W. and Margolin, B.H.  Quantitative methods for assessing a synergistic or potentiated genotoxic response. Mutation Research 216, 1-8 (1989).

Piegorsch, W.W.  Quantification of toxic response and the development of the median effective dose (ED50) - An historical perspective. Toxicology and Industrial Health 5, 55-62 (1989).

Piegorsch, W.W. and Casella, G.  Confidence bands for logistic regression with restricted predictor variables. Biometrics 44, 739-750 (1988).

Piegorsch, W.W. and Hoel, D.G.  Exploring relationships between mutagenic and carcinogenic potencies. Mutation Research 196, 161-175 (1988).

Dunnick, J.K., Eustis, S.L., Piegorsch, W.W., and Miller, R.A. Respiratory tract lesions in F344/N rats and B6C3F1 mice after exposure to 1,2-Epoxybutane. Toxicology 50, 69-82 (1988).

Piegorsch, W.W., Weinberg, C.R., and Margolin, B.H. Exploring simple independent action in multifactor tables of proportions. Biometrics 44, 595-603 (1988).

Piegorsch, W.W. Model robustness for simultaneous confidence bands. Journal of the American Statistical Association 82, 879-885 (1987).

Kitamura, H., Inayama, I., Ito, T., Yanaba, M., Piegorsch, W.W., and Kanisawa, M. Morphologic alteration of mouse Clara cells induced by glycerol: ultrastructural and morphometric studies. Experimental Lung Research 12, 281-302 (1987).

Piegorsch, W.W. Performance of likelihood-based interval estimates for two-parameter exponential samples subject to type I censoring. Technometrics 29, 41-49 (1987).

Rao, G.N, Piegorsch, W.W., and Haseman, J.K.  Influence of body weight on the incidence of spontaneous tumors in rats and mice of long term studies. American Journal of Clinical Nutrition 45, 252-260 (1987).

Piegorsch, W.W. and Weinberg, C.R.  Testing for synergistic effects for simultaneous exposures with stratified dichotomous response. Journal of Statistical Computation and Simulation 26, 1-19 (1986).

Piegorsch, W.W., Weinberg, C.R., and Haseman, J.K.  Testing for simple independent action between two factors for dichotomous response data. Biometrics 42, 413-419 (1986).

Piegorsch, W.W. Confidence bands for polynomial regression with fixed intercepts. Technometrics 28, 241-246 (1986).

Piegorsch, W.W. The Gregor Mendel controversy: Early issues of goodness-of-fit and recent issues of genetic linkage. History of Science 24, 173-182 (1986).

Piegorsch, W.W. Average width optimality for confidence bands in simple linear regression. Journal of the American Statistical Association 80, 692-697 (1985).

Piegorsch, W.W. Admissible and optimal confidence bands in simple linear regression. Annals of Statistics 13, 801-810 (1985).

Piegorsch, W.W. and Casella, G.  The existence of the first negative moment. American Statistician 39, 60-62 (1985).

Piegorsch, W.W. The questions of fit in the Gregor Mendel controversy. Communications in Statistics — Theory and Methods 24, 173-182 (1983).


SELECTED TECHNICAL REPORTS:

Piegorsch, W.W. and Casella, G. Empirical Bayes estimation for generalized linear models.
Biometrics Unit Mimeo Series #BU-1067-M, Cornell University, Ithaca, NY (1990).

Piegorsch, W.W. Tables of P-values for t- and Chi-square Reference Distributions. Technical Report #194, Department of Statistics, University of South Carolina, Columbia, SC (2002).

Lin, L., St. Thomas, B., Piegorsch, W.W., Scott, J., and Carvalho, C. A projection approach for multiple monotone regression. arXiv:1911.07553 [stat.ME] (2019).


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